July 1, 2026 - MORNING SESSION
8:00 – 9:00 Registration
8:55 – 9:00 Welcome Address
Csaba Szabo, University of Fribourg, Fribourg, Switzerland
9:00 – 10:00 Keynote Lecture: Posttranslational Protein Modifications by Gaseous Transmitters
Jonathan Stamler, Case Western Reserve University, Cleveland, OH, USA
Session 1: H2S Biochemistry and Signalling (Chairs: M. Whiteman & M. Filipovic)
10:00 – 10:30 State-of-the-Art Lecture: Catalytic and Scaffolding Functions and Supramolecular Organization of CBS Tomas Majtan, University of Fribourg, Fribourg, Switzerland
10:30 – 10:50 Lecture: Modulation of Protein S-Cysteinylation by Human CBS and CSE João B. Vicente, Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Oeiras, Portugal
10:50 – 11:10 Lecture: H2S Regulates Intracellular Oxygen and HIF Signaling Joseph Brake, Department of Biological Chemistry, University of Michigan, USA
11:00 – 11:45 Coffee break + Poster viewing
11:45 – 12:00 Lecture: Modulation of Human H2S Catabolism by Nitric Oxide through Inhibition of Persulfide Dioxygenas Alessandro Giuffrè, CNR Institute of Molecular Biology and Pathology, Rome, Italy.
12:00 – 12:15 Lecture: The Transsulfuration Pathway in Skeletal Muscle Pathophysiology
Mariarosaria Bucci, University of Naples, Naples, Italy
12:15 – 12:30 Lecture: Targeting Antibiotic Resistance and Tolerance by First-in-Class Inhibitors of Bacterial H₂S Biogenesis
Konstantin Shatalin, New York University, New York, NY, USA
12:30 – 12:45 Lecture: H2S Tolerance and Catabolism in the Multidrug-Resistant Pathogen Pseudomonas aeruginosa Elena Forte, Department of Biochemical Sciences, Sapienza University of Rome, Italy
12:45 – 13:00 Lecture: Endogenous H2S Shapes Metabolic Adaptation in Mycobacterium tuberculosis Vikram Saini, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
13:00 – 14:00 LUNCH BREAK
July 1, 2026 - AFTERNOON SESSION
Session 2: H2S in Metabolism and Aging (Chairs: A. Papapetropoulos & P. Nagy)
14:00 – 14:30 State-of-the-Art Lecture: Regulation of Whole-Body Metabolism and Obesity by H2S-Producing Enzymes
Andreas Papapetropoulos, University of Athens, Athens, Greece
14:30 – 15:00 Plenary Lecture: Effects of Ergothioneine on Healthspan via CSE-Dependent Persulfidation
Milos Filipovic, University of Glasgow, Glasgow, Scotland, UK
15:00 – 15:20 Lecture: H2S Signalling and Exercise Intolerance in Cardiometabolic Disease
Timothy D. Allerton, Pennington Biomedical Research Center, Baton Rouge, LA, USA
15:20 – 15:35 Brief Oral Presentation: Mechanisms Mediating Stimulatory Effects of H2S on Insulin Secretion Ian Sweet, University of Washington, Seattle, WA, USA
15:35 – 15:50 Brief Oral Presentation: Identification of Chaperones that Restore CBS Activity in Homocystinuria Maria Petrosino, University of Fribourg, Fribourg, Switzerland
15:50 – 16:20 Coffee break + Poster viewing
16:20 – 17:20 Oral Poster Presentations (5 minutes each)
Oral Poster 1: Protein Persulfidation Protects from Sulfonylation-Driven Aggregation by Dissolving Biomolecular Condensates – Jovan Petric, University of Glasgow, Glasgow, Scotland, UK
Oral Poster 2: FGF21 Reduces ER-Stress by Enhancing the Unfolded Protein- and Integrated Stress Response through Increased Sulfide Signaling – Gerard Grandl, Institute of Diabetes and Obesity, Helmholtz Munich, Munich, Germany
Oral Poster 3: Cysteine Oxidation as a Regulator of the A Subunit of the Vacuolar ATPase in Saccharomyces Cerevisiae – Mariana Michell García-Reyes, UNAM, Mexico City, Mexico
Oral Poster 4: Pharmacological CSE Inhibition Rewires Hepatic Sulfur and Lipid Metabolism and Attenuates Metabolic-Associated Fatty Liver Disease – Silke Griepke, University of Southern Denmark, Odense, Denmark
Oral Poster 5: Global Deletion of 3-MST Results in Albuminuria – Paraskevas Zampas, University of Athens, Athens, Greece
Oral Poster 6: CSE Inhibition in LSEC Results in Lower eNOS activation and Impaired Capillarization and Fenestration under Metabolic-Associated Fatty Liver Disease-Like Conditions – Odysseia Savvoulidou, University of Southern Denmark, Odense, Denmark
Oral Poster 7: Cell-specific Effects of 3-MST in Obesity – Konstantinos Salagiannis, University of Athens, Athens, Greece
17:20 END OF SESSIONS
19:30 – 21:30 SPEAKERS' SAB MEMBER' DINNER (per invitation)
July 2, 2026 - MORNING SESSION
Session 3: H2S and the Cardiovascular System (Chairs: D. Lefer & G. Cirino)
8:30 – 9:00 State-of-the-Art Lecture: H2S Signalling in Heart Failure
David Lefer, Cedars-Sinai Medical Center, Los Angeles, CA, USA
9:00 – 9:30 Plenary Lecture: Hypoxic Regulation of Sulfane Sulfur Formation in the Vasculature
Christopher Kevil, LSU Health Shreveport, Shreveport, LA, USA
9:30 – 10:00 Plenary Lecture: Role of CSE-Derived H2S in the Cardiovascular System
Giuseppe Cirino, University of Naples, Naples, Italy
10:00 – 10:30 Plenary Lecture: Interaction Between H2S and NO in the Cardiovascular System
Jingsong Bian, Southern University of Science and Technology, Shenzhen, China
10:30 – 11:00 Coffee break + Poster viewing
11:00 – 11:15 Lecture: Reactive Sulfide Species in Vascular Cognitive Impairment and Dementia in Aging
Gopi Kolluru, LSU Health Shreveport, Shreveport, LA, USA
11:15 – 11:30 Lecture: Holding Iron Responsible: H2S Signalling in Vascular Smooth Muscle Function
Guangdong Yang, Laurentian University, Sudbury, Canada
11:30 – 12:00 Oral Poster Presentations (5 minutes each)
Oral Poster 8: 3-MST is Essential for the Cardioprotective Action of Sodium Thiosulfate in Myocardial Ischemia/Reperfusion Injury – Stella Ravani, University of Athens, Athens, Greece
Oral Poster 9: Role of the Endocannabinoid System in the Anxiolytic and Antidepressant-Like Mechanisms of Dimethyl Trisulfide in a Chronic Stress Model – Kitti Gönter, University of Pécs, Pécs, Hungary
Oral Poster 10: Dysregulated eNOS Persulfidation as a Driver of Endothelial Dysfunction in Type 1 Diabetes – Martina Smimmo, University of Naples, Naples, Italy
12:00 – 13:00 LUNCH BREAK
July 2, 2026 - AFTERNOON SESSION
Session 4: H2S and Cancer (Chairs: C. Szabo & C. Bourquin)
13:00 – 13:30 State-of-the-Art Lecture: H2S Signalling in Cancer Cells
Peter Nagy, National Institute of Oncology, Budapest, Hungary
13:30 – 13:50 Lecture: Insights into Reactive Sulfur Species Regulation of Cancer Cell Death
Moran Benhar, Technion – Israel Institute of Technology, Haifa, Israel
13:50 – 14:10 Hydrogen Sulfide Donation in Cancer Kashrow Kashfi, City University of New York, New York, NY, USA
14:10 – 14:30 Lecture: Anticancer Effects of D-Cysteine
Roland Lill, University of Marburg, Marburg, Germany
14:30 – 14:50 Lecture: H2S and Anticancer T-Cell Responses
Carole Bourquin, University of Bern, Bern, Switzerland
14:50 – 15:10 Lecture: Sulfide Oxidation and Age Leverage the Tumor-Supportive versus Tumor-Suppressive Properties of Hydrogen Sulfide in Glioblastoma Christopher Hine, Case Western Reserve University, Cleveland, OH, US
15:10 – 15:25 Short Oral Presentation: Pathway-Specific Persulfidation Shifts and Altered Sulfide Signaling Contribute to Esophageal Metaplasia Development Marcin Magierowski, Jagiellonian University Medical College (JUMC), Krakow, Poland
15:25 – 15:35 Short Oral Presentation: Role of 3-MST in Colon Cancer Stem Cells
Kelly Ascencao, University of Fribourg, Fribourg, Switzerland
15:35 – 15:45 Oral Poster Presentations (5 minutes each)
Oral Poster 11: Selective Allosteric Inhibition of CSE as a Broad Anticancer Strategy – Maureen Brusco, New York University, New York, NY, USA
Oral Poster 12: H₂S Modulates CD8⁺ T Cell-Mediated Antitumor Responses – Marietta Korsos, University of Bern, Bern, Switzerland
15:45 – 16:10 Coffee break + Poster viewing
Session 5: H2S and the Nervous System (Chairs: B. Paul & H. Kimura)
16:10 – 16:45 State-of-the-Art Lecture: Role of H2S in Age-Related Neurodegeneration
Bindu D. Paul, Johns Hopkins University, Baltimore, MD, USA
16:45 – 17:15 State-of-the-Art Lecture: Roles of H2S in the Central Nervous System
Hideo Kimura, Sanyo-Onoda City University, Yamaguchi, Japan
17:15 – 17:35 Lecture: Regulatory Roles of H2S in Peripheral Nerves
Erika Pintér, University of Pécs, Pécs, Hungary
17:35 – 17:55 Lecture: Sulfide Catabolism in Neurodegenerative Disorders
Fumito Ichinose, Harvard University, Boston, MA, USA
17:55 – 18:10 Brief Oral Presentation: Neuronal-Glial Interactions and CBS in Down Syndrome
Theodora Panagaki, University of Fribourg, Fribourg, Switzerland
18:10 – 18:20 Brief Oral Presentation: Anxiolytic and Antidepressant Effects of Organic Polysulfide, Dimethyl Trisulfide Are Partly Mediated by the Transient Receptor Potential Ankyrin 1 Ion Channel in Mice
Gábor Pozsgai, University of Pécs, Pécs, Hungary
18:20 END OF SESSIONS
19:00 – 22:30 GALA DINNER: Salle Grenette, Place de Notre-Dame 4, 1700 Fribourg
July 3, 2026 - MORNING SESSION
Session 6: Diagnostic and Therapeutic Modulation of H2S (Chairs: J. Miljkovic & M. Pluth)
9:00 – 9:30 State-of-the-Art Lecture: Organelle-Targeted Sulfide Delivery
Mathew Whiteman, University of Exeter, Exeter, UK
9:30 – 9:50 Lecture: Mitochondrially Targeting Persulfide and H2S
Jan Miljkovic, University of Cambridge, Cambridge, UK
9:50 – 10:10 Lecture: Targeted H2S Donors that Self-Assemble Anticancer Benzoxazoles
John C. Lukesh, Wake Forest University, Winston-Salem, NC, USA
10:10 – 10:30 Lecture: Leveraging Sulfurtransferases to Enhance Hydropersulfides for Therapeutic Applications
Harinath Chakrapani, Indian Institute of Science Education and Research Pune, Pune, India
10:30 – 10:50 Coffee break + Poster viewing
10:50 – 11:10 Lecture: From Engineered Molecules to Cells: Multimodal Probing of H2S
Enver Çağrı İzgu, Rutgers University, New Brunswick, NJ, USA
11:10 – 11:25 Brief Oral Presentation: Isothiocyanates as Protein-Engaged H2S Donors
Jing Yang, Guangzhou National Laboratory, Guangzhou, China
11:25 – 11:35 Brief Oral Presentation: Caffeic Acid Phenethyl Ester Enhances Cavernosal Relaxation Through an H2S-Dependent Mechanism Gunay Yetik Anacak, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Türkiye
11:35 – 11:45 TBA
11:45 – 12:25 Oral Poster Presentations (5 minutes each)
Oral Poster 13: Liver-Specific Expression of SQR Rescues Mice with Leigh-Like Brain Disease – Kakeru Shimoda,Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Oral Poster 14: Protective Effect of H2S Donors in Preventing Diabetic Liver Damage via Ferroptosis Inhibition in Mice – Nevena Savic, University of Belgrade, Belgrade, Serbia
Oral Poster 15: H2SWITCH: A Genetically Encodable Tool for Tunable Generation of Intracellular H2S – Asal Ghaffari Zaki, Istanbul Medipol University, Istanbul, Türkiye
Oral Poster 16: A Novel H₂S-Releasing Ibuprofen Derivative with Special Release Kinetics Mitigates Doxorubicin-Induced Cardiac Injury – Eskeif Simon, University of Debrecen, Debrecen, Hungary
Oral Poster 17: Targeting Reperfusion Injury with a Novel ROS-Responsive Thiometallate Sulfide Donor – Khalid S. Alotaibi, University College London, London, UK
Oral Poster 18: A Resveratrol–H2S Donor Hybrid as a Multi-Target Therapeutic Strategy for Allergic Asthma – Martina Simonellia, University of Naples, Naples, Italy.
Oral Poster 19:Salvia Miltiorrhiza Derived Natural Compounds are Potent Inhibitors of 3-MST – Olivia Oravetz, University of Fribourg, Fribourg, Switzerland
Session 7: Emerging Gaseous Transmitters and Mediators (Chairs: H. Kimura & F. Ichinose)
12:25 – 12:45 Lecture: Homeostatic Impact of Sulfite on H2S, Persulfides, and Glutathione in Health and Disease
Günter Schwarz, University of Cologne, Cologne, Germany
12:45 – 13:00 Lecture: Methanethiol, an Emerging Mammalian Gaseous Regulator
Thilo Philipp, University of Fribourg, Fribourg, Switzerland
13:00 – 13:10 Oral Poster Presentation (5 minutes)
Oral Poster 20: Anti-Senescent Effects of SelenBP1 in Endothelial Cells – Anne Sophie Scheller, University of Jena, Jena, Germany
13:10 – 14:00 LUNCH BREAK
July 3, 2026 - AFTERNOON SESSIONS
Session 8: Cyanide, a Novel Mammalian Gaseous Transmitter (Chairs: B. Logue & G. Boss)
14:00 – 14:30 State-of-the-Art Lecture: Endogenous Cyanide Signalling Pathways in Health and Disease
Csaba Szabo, University of Fribourg, Fribourg, Switzerland
14:30 – 15:00 Plenary Lecture: Cyanide Neutralization Methods
Gerry Boss, University of California San Diego, La Jolla, CA, USA
15:00 – 15:30 Coffee break + Poster viewing
15:30 – 16:00 Plenary Lecture: Cyanide Detection Methods
Brian Logue, South Dakota State University, Brookings, SD, USA
16:00 – 16:20 Lecture: Chemical Tools for Investigating Biological Cyanide
Michael Pluth, University of Oregon, Eugene, OR, USA
16:20 – 16:40 Lecture: Investigation of Hemoglobin Interactions with Cyanide and Other Gasotransmitters within Red Blood Cells using Resonance Raman Spectroscopy Jakub Dybas, Jagiellonian University, Krakow, Poland
16:40 – 17:00 Lecture: Hijacking a Toxin: How Hydrogen Cyanide Functions as an Immune Signal in Plants Irene García, Spanish National Research Council(CSIC),Sevilla, Spain
17:00 – 17:20 Lecture: Endogenous Cyanide Accumulation in Aging
Karim Zuhra, University of Fribourg, Fribourg, Switzerland
17:20 – 17:35 Brief Oral Presentation: The Role of Endogenous Cyanide Formation in Lifespan and Healthspan Regulation of C Elegans
Yiorgos Paikopoulos, University of Glasgow, Glasgow, Scotland
17:35 – 17:50 Oral Poster Presentations
Oral Poster 21: Endogenous Cyanide Generation by Pseudomonas aeruginosa Suppresses Host Immune Response– Sidneia Sousa Santos, University of Fribourg, Fribourg, Switzerland
Oral Poster 22: Endogenous Cyanide Regulates Endothelial Cell Function– Anna Kieronska-Rudek, Jagiellonian University, Krakow, Poland
Oral Poster 23: Cyanide Donor Therapy Improves Endothelial Function in ApoE/Ldlr-/- Mice – Edyta Kus, Jagiellonian University, Krakow, Poland
17:50 – 18:20 CLOSING CEREMONY
Final Remarks
Young Investigator Award Presentation
Announcement of the Location of the Next Meeting
